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FAPI Nanoprobe: Dual-Cell Ferroptosis and ‘Light-Up’ MRI for Gastric Cancer Metastasis

Technology Innovation /

Gastric cancer peritoneal metastasis (PM) is driven by a protective tumor microenvironment (TME), with cancer-associated fibroblasts (CAFs) contributing to therapy resistance via high GPX4 levels that prevent ferroptosis. To overcome this barrier, researchers developed a multifunctional theranostic nanoplatform, CDDP2@MSPION@GP3/FAPI. This system combines iron oxide nanoparticles (MSPION) that release Fe²⁺/Fe³⁺ in the acidic TME to trigger […]

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Brain Cells Fuel Cancer’s Deadly Spread

Research Advances /

Cancer neuroscience explores how the nervous system influences tumor development. In primary brain tumors like glioma and glioblastoma, neurons promote growth through factors such as BDNF and neuroligin-3. Glioma cells form excitatory synapses with neurons and develop neuronal-like features, including “tumor microtubes” that facilitate communication and proliferation. Outside the brain, the peripheral nervous system regulates

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Environmental and Lifestyle Factors in Gynecological Cancers: Risk and Prevention

News /

Environmental exposures and lifestyle behaviors are major, yet modifiable, drivers of cancer, accounting for nearly half of all cases globally. These factors are particularly influential in female cancers, where risks include smoking, obesity, poor diet, air pollution, and unsafe sexual practices. Protective measures such as oral contraceptives and a Mediterranean diet can lower risk in

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Claspin: A Dual-Role Regulator in Cancer Biology and Therapeutic Resistance

Treatment /

Cancer arises from uncontrolled cell growth and genomic instability, often due to defective checkpoints and DNA repair mechanisms. Claspin is a key regulator in this process, acting as a scaffold protein that activates the ATR-Chk1 checkpoint in response to DNA damage or replication stress. By pausing the cell cycle, Claspin allows DNA repair or triggers

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WTX-124 Fast-Tracked by FDA for Melanoma After Immunotherapy Failure

Research Advances /

The FDA has granted fast track designation to WTX-124, a conditionally activated interleukin-2 (IL-2) therapy, for patients with locally advanced or metastatic cutaneous melanoma after standard immunotherapy. WTX-124, designed to deliver IL-2 selectively to tumors and reduce systemic toxicity, is being studied as monotherapy and in combination with pembrolizumab in a phase 1/1b trial for

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IDE397 Plus Trodelvy Shows Strong Early Efficacy in MTAP-Deleted Urothelial Cancer

Treatment /

A phase 1/2 trial evaluating IDE397, a MAT2A inhibitor, combined with sacituzumab govitecan-hziy (Trodelvy) shows encouraging activity in late-line MTAP-deletion urothelial cancer. Two expansion cohorts were assessed. Dose Level 1 (IDE397 15 mg + Trodelvy 10 mg/kg, n=9) achieved a 33% objective response rate (ORR) and 100% disease control rate (DCR). Dose Level 2 (IDE397

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Dostarlimab Boosts Survival in Advanced Endometrial Cancer

Treatment /

Endometrial cancer, the second most common gynecologic malignancy, is typically treated with carboplatin and paclitaxel, but outcomes remain poor. The Phase 3 RUBY trial evaluated adding the anti–PD-1 drug dostarlimab to this regimen in 494 patients with newly diagnosed advanced or recurrent disease. Dostarlimab significantly improved results: in patients with mismatch repair–deficient or MSI-high tumors,

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GRAPE: An AI-Powered Revolution in Opportunistic Gastric Cancer Screening

Diagnostics /

Gastric cancer (GC) is a leading cause of cancer death globally. Early diagnosis is critical, as the five-year survival rate drops from up to 99% for early-stage GC (EGC) to under 30% for advanced stages. While standard endoscopy screening has lowered mortality in some countries, it is generally too expensive and invasive for large-scale public

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Tumor Bacteria Produce Molecule That Enhances Chemotherapy and Fights Cancer

Molecular Oncology /

International scientists discovered that bacteria living in tumors produce a molecule called 2-methylisocitrate (2-MiCit) that can fight cancer and enhance chemotherapy effectiveness. Through screening over 1,100 conditions using C. elegans worms, scientists found that E. coli bacteria produce 2-MiCit, which improves the effectiveness of the chemotherapy drug 5-fluorouracil (5-FU). The molecule works by inhibiting a

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