li001

Blood Test Detects HPV-Linked Head and Neck Cancer a Decade Before Symptoms

A new study from Mass General Brigham published in the Journal of the National Cancer Institute reports a major advance in early detection of HPV-linked head and neck cancer. The new blood test, called HPV-DeepSeek, uses whole-genome sequencing to find tiny fragments of HPV DNA in the bloodstream. It was able to detect cancer up to […]

Blood Test Detects HPV-Linked Head and Neck Cancer a Decade Before Symptoms Read More »

OST-HER2 Immunotherapy Shows 75% Two-Year Survival in Recurrent Pulmonary Osteosarcoma

The off-the-shelf immunotherapy OST-HER2 (OST31-164) demonstrated impressive 2-year overall survival results in a phase 2b trial for patients with recurrent, fully resected pulmonary metastatic osteosarcoma. The 2-year overall survival rate reached 75% among evaluable patients (n=36), significantly higher than the historical control rate of 40% (P<.0001). Patients who achieved an event-free survival (EFS) of at

OST-HER2 Immunotherapy Shows 75% Two-Year Survival in Recurrent Pulmonary Osteosarcoma Read More »

Abemaciclib Delivers 84% Response Rate in Kaposi Sarcoma, Including HIV-Positive Patients

Abemaciclib Shows High Efficacy in Kaposi Sarcoma, Including HIV-Associated Cases A phase 1/2 trial (NCT04941274) presented at the 2025 ASCO Annual Meeting found that the CDK4/6 inhibitor abemaciclib (Verzenio) was well-tolerated and demonstrated strong antitumor activity in both HIV-associated and HIV-negative Kaposi sarcoma. Among 31 efficacy-evaluable patients, the overall response rate (ORR) was 84%. Patients

Abemaciclib Delivers 84% Response Rate in Kaposi Sarcoma, Including HIV-Positive Patients Read More »

New Liquid Biopsies and AI-Powered Tests Promise a Future of Earlier Colorectal Cancer Detection

Colorectal cancer (CRC) is rising worldwide, particularly early-onset cases, creating an urgent need for earlier detection to improve survival. Traditional screening methods have limitations: colonoscopy is invasive and resource-intensive, while stool-based tests like FIT often miss early-stage cancers. CRC arises from adenomas through cumulative mutations (e.g., APC, KRAS, TP53) and exhibits molecular heterogeneity, classified into

New Liquid Biopsies and AI-Powered Tests Promise a Future of Earlier Colorectal Cancer Detection Read More »

Immunotherapy Combination Shows Durable 5-Year Survival in Advanced Liver Cancer

The HIMALAYA phase III study demonstrated that the STRIDE regimen (Single Tremelimumab Regular Interval Durvalumab) provides a sustained and clinically meaningful overall survival (OS) benefit compared to sorafenib for patients with previously untreated, unresectable hepatocellular carcinoma (uHCC). The 5-year follow-up data established a new survival benchmark in uHCC, showing a 60-month (5-year) OS rate of 19.6% for STRIDE versus

Immunotherapy Combination Shows Durable 5-Year Survival in Advanced Liver Cancer Read More »

Targeting Lactylation Offers New Hope for Treatment-Resistant Cancers

Cancer cells often rely on an inefficient energy process known as the Warburg effect, where glucose is converted to lactate even in the presence of oxygen. This excess lactate is not merely waste—it fuels an epigenetic process called lactylation. In lactylation, lactate is transformed into lactyl-CoA and attached to lysine residues on histone and non-histone

Targeting Lactylation Offers New Hope for Treatment-Resistant Cancers Read More »

Scientists Develop ‘Invisible’ Cancer-Fighting Cells That Evade Immune Rejection

Scientists have developed a breakthrough method for engineering CAR-NK (natural killer) cells—an advanced, immune-based cancer therapy. This innovation, from MIT and Harvard Medical School, overcomes the critical limitation of cell-based therapies: immune rejection of donor cells. The key is a single-step genetic construct that modifies donor NK cells to both express the cancer-targeting Chimeric Antigen Receptor (CAR) and silence

Scientists Develop ‘Invisible’ Cancer-Fighting Cells That Evade Immune Rejection Read More »

Medical Imaging in Cancer of Unknown Primary: Current Standards and Future Directions

Cancer of unknown primary (CUP) accounts for 2%–5% of new cancer diagnoses and is defined by the presence of metastatic disease without an identifiable primary tumor despite extensive investigation. Due to its complexity and heterogeneity, CUP carries a poor prognosis, contributing to around 8% of all cancer-related deaths, with only 16%–20% of patients surviving beyond

Medical Imaging in Cancer of Unknown Primary: Current Standards and Future Directions Read More »

Photoacoustic Imaging: A New Frontier in Breast Cancer Detection and Real-Time Monitoring

Breast cancer incidence is rising globally, making it the leading cause of cancer death in women. Conventional imaging—mammography, ultrasound, and MRI—remains essential but limited: mammography performs poorly in dense breasts, ultrasound is operator-dependent with low specificity, and MRI is costly, slow, and unsuitable for real-time monitoring. This highlights the need for a fast, safe, and

Photoacoustic Imaging: A New Frontier in Breast Cancer Detection and Real-Time Monitoring Read More »

New Cancer Target Offers Hope for Personalized Treatment

CLDN18.2, a stomach-specific tight junction protein, is normally low but becomes upregulated in multiple cancers, including gastric, pancreatic, colorectal, breast, and liver tumors. This dysregulation promotes tumor growth and spread, making it a promising biomarker and therapeutic target. Its expression is regulated by transcriptional, epigenetic, and signaling pathways, and it has context-dependent effects—mostly oncogenic, but

New Cancer Target Offers Hope for Personalized Treatment Read More »