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Breast cancer recurrence, sometimes decades after initial treatment, is driven by dormant cancer cells that evade therapy. Researchers are focusing on understanding these cells and the “treatment window” between initial therapy and potential reawakening. Dormant cells often reside in protective niches, like bone marrow, where surrounding cells shield them from treatment. Key survival mechanisms include

A daily low-dose aspirin may cut colorectal cancer recurrence in patients with PI3K pathway mutations, present in about one-third of cases. The ALASCCA trial found that 160 mg of aspirin daily for three years reduced recurrence risk by 55% versus placebo, benefiting patients across different PI3K gene alterations (PIK3CA, PIK3R1, PTEN) and cancer stages. Aspirin

An international research team has discovered that extrachromosomal DNA (ecDNA) rings, which float outside chromosomes, can drive the early development of glioblastoma, the most aggressive adult brain cancer. The study, published in Cancer Discovery, shows that ecDNA containing cancer-driving genes, especially EGFR, often appears before tumors fully form, fueling rapid growth, adaptability, and treatment resistance.