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A recent study found that leukemia patients exposed to chemotherapy showed lower glucose metabolism in specific brain regions when examined with F-18 FDG-PET/CT imaging. PET/CT identified metabolic alterations—decreased glucose uptake—in chemotherapy-exposed individuals compared to controls, specifically in the posterior cingulate gyrus, anterior orbital gyrus, and thalami. These metabolic changes, which occur in areas governing cognition […]

Scientists have developed new compounds that block the interaction between the RAS gene and the PI3K enzyme, a key driver of cancer growth, while sparing normal cellular functions. RAS mutations keep the gene permanently active, causing uncontrolled cell proliferation, but directly targeting RAS or PI3K has been challenging due to their roles in essential processes

Scientists have shown that boosting the body’s natural immune defenses can prevent cancer recurrence and improve survival in mouse models of multiple cancers. Published in Nature Immunology, the study demonstrates how transforming “immune-cold” tumors—which typically evade immune detection—into “immune-hot” ones can make them more responsive to immune attack. The researchers achieved this transformation by inducing

Immunotherapy has revolutionized cancer treatment but remains less effective against liver cancer, whose incidence has nearly tripled in recent years. Scientists discovered that certain bile acids produced by the liver can suppress cancer-fighting T cells. Harmful bile acids such as LCA and TCDCA cause stress and oxidative damage to T cells, weakening their ability to

Researchers have identified KCTD10 as a key “traffic controller” for DNA, coordinating the essential processes of replication and transcription to maintain genomic stability. During cell division, replication machinery rapidly duplicates DNA, while transcription machinery reads it to produce RNA. Collisions between these processes can cause DNA damage, double-strand breaks, and mutations that drive cancer. KCTD10