Research Advances

Researchers are developing a new nanotechnology-based treatment strategy for pancreatic cancer that aims to overcome two major barriers: the tumor’s dense protective tissue and its ability to suppress the immune system. The approach uses smart nanomaterials designed to trigger a form of cancer cell death called ferroptosis, which depends on iron and causes toxic damage […]

Researchers have discovered that vitamin B2, also known as riboflavin, helps cancer cells survive by protecting them from ferroptosis, a type of cell death caused by iron-driven oxidative damage. The study, published in Nature Cell Biology, found that vitamin B2 supports a protein called FSP1, which strengthens the antioxidant defenses of tumor cells and prevents

A study published in Communications Biology has identified pyruvate carboxylase (PC) as a key driver of metabolic changes in epithelial ovarian cancer. Researchers found that high PC levels are linked to more advanced disease, metastasis, recurrence, and poorer survival. The study shows that PC helps cancer cells build up fats by boosting the production of triglycerides

A new study shows that CRISPR gene editing may help protect patients with Acute Myeloid Leukemia from the harmful side effects of intensive cancer treatment. In the VBP101 trial, researchers used CRISPR-Cas9 to remove the CD33 protein from donor stem cells before transplant. This created a new blood and immune system that could resist damage

Researchers have developed a new way to eliminate harmful “zombie cells” linked to cancer and aging. These senescent cells stop dividing but remain active, releasing substances that can damage tissue and help tumors spread. Scientists discovered that the cells survive by overproducing GPX4, a protein that protects them from Ferroptosis, a form of cell death

A study published in Blood found that the success of the T-cell engager glofitamab in relapsed or refractory large B-cell lymphoma (LBCL) depends heavily on the health and strength of a patient’s T cells. Researchers analyzed patients from the Phase 1/2 NP30179 trial and discovered that patients who responded well to treatment maintained higher levels of

Researchers have developed an experimental cancer therapy called aurB that kills tumors by blocking their energy production. Inspired by bacteria living inside tumors, scientists created aurB from a bacterial protein called auracyanin. The therapy targets mitochondria, the cell’s energy source, and blocks ATP synthase, an enzyme needed to produce energy. Without energy, cancer cells struggle

Doctors are warning cancer patients to be cautious about taking biotin supplements for hair and nail growth because the vitamin can interfere with important blood tests. Although biotin, also known as vitamin B7, is often promoted online as a harmless beauty supplement, experts say it can create misleading lab results that may affect cancer care.

Researchers have developed a new lipid analysis method that could improve early detection of pancreatic cancer by identifying hidden changes in blood fat molecules. The technique combines advanced mass spectrometry with specialized software to detect detailed lipid structures that standard tests often miss. The study analyzed 15 lipid classes, including ceramides and sphingomyelins, using a

A study published in PNAS shows how pancreatic cancer cells develop resistance to a targeted therapy in Pancreatic ductal adenocarcinoma. Researchers focused on the KRAS inhibitor MRTX-1133, which initially blocks tumor growth by shutting down a key cancer-driving pathway. However, cancer cells quickly adapt by increasing levels of a protein called Fra-2. This triggers a