Research Advances

A new study has identified Prolyl 3-hydroxylase 1 (P3H1) as an important driver of pancreatic ductal adenocarcinoma (PDAC) and a potential new treatment target. Researchers found that P3H1 is highly expressed in both human and mouse pancreatic tumors. Patients with higher P3H1 levels tended to have more advanced disease and shorter disease-free survival. In mouse […]

A study has found a link between severe respiratory infections and a higher long-term risk of lung cancer. Researchers discovered that serious infections such as COVID-19, influenza, or pneumonia can leave the lungs in a long-lasting inflammatory state that may encourage tumor development. The research showed that patients who were hospitalized for COVID-19 had about

A recent study highlights a mismatch between PSA blood tests and PSMA-PET scans in tracking prostate cancer. While patients taking enzalutamide saw PSA levels drop dramatically—sometimes to 0 ng/mL—their PSMA scans often showed remaining tumor or even slight increases in tumor volume. This suggests that the two measures do not always align. Experts warn that

Scientists have discovered a key reason why Small Cell Lung Cancer often resists immunotherapy. Their research shows that the tiny blood vessels around the tumor act like a barrier, preventing immune cells from entering the cancer and attacking it. In theory, these tumors should be vulnerable to attack by Natural Killer cells because many small

Researchers have developed a new experimental molecule that could offer a promising treatment option for aggressive Triple-Negative Breast Cancer, a form of breast cancer that currently has limited targeted therapies. The molecule, called SU212, works by targeting and breaking down an enzyme known as ENO1 (enolase 1). Cancer cells often produce large amounts of this

A new study highlights how defects in the TP53-mediated apoptosis pathway affect survival in adult Acute Myelogenous Leukemia (AML), even when the TP53 gene appears normal. Mutations in TP53 are well-known markers of poor prognosis because they allow leukemia cells to resist chemotherapy and accumulate additional mutations. However, researchers found that a significant portion of

Researchers have discovered a new survival strategy used by pancreatic cancer cells: sharing protein-making machinery through tiny cellular bridges called tunneling nanotubes (TNTs). Pancreatic ductal adenocarcinoma (PDAC) cells use these tubes to exchange messenger RNA, ribosomal components, and even fully assembled ribosomes, effectively supplying each other with the tools needed to make proteins and survive.

A study has identified specific cancer-associated fibroblasts (CAFs) as key drivers of invasion and progression in aggressive Thyroid Cancer. By mapping the tumor stroma, researchers found that these cells create a microenvironment that promotes metastasis and resistance to treatment. The researcher used single-cell sequencing and spatial transcriptomics to analyze 81 patient samples, comparing slow-growing tumors with

Researchers have discovered a way that metastatic tumor cells avoid the immune system in Triple-Negative Breast Cancer (TNBC). The study, led by Judith Agudo and published in Nature, describes how cancer cells traveling through the body can hide from immune attack and form tumors in organs such as the lungs, liver, and brain. Using a

A new study found that a protein called Secreted Phosphoprotein 1 (SPP1) plays an important role in helping colorectal cancer spread to the liver and resist immunotherapy. Researchers discovered that SPP1 levels are much higher in liver metastases than in primary colorectal tumors. Patients with high levels of SPP1 in their blood tend to have