News

Triple-Drug Therapy Erases Pancreatic Tumors in Mice, Raising Hope for Future Treatment

preclinical trails /

Researchers have developed a new three-drug treatment that completely eliminated pancreatic tumors in mice and stopped them from coming back. This is a major advance for pancreatic cancer, a disease with a five-year survival rate of about 13%. The therapy works by blocking three critical pathways that pancreatic tumors use to survive and grow. It […]

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FDA Approves Rybrevant Faspro Subcutaneous Injection for Faster Lung Cancer Treatment

Drug Approvals /

The FDA has approved Rybrevant Faspro (amivantamab with hyaluronidase) as a subcutaneous injection for adults with EGFR-mutated non-small cell lung cancer, covering all previous intravenous indications. The subcutaneous version works as well as the IV form, with similar effectiveness and overall survival, but can be given in about 5 minutes instead of 2–5 hours. It also greatly

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FDA Approves Darzalex Faspro Combo for Newly Diagnosed Multiple Myeloma Patients Ineligible for Transplant

Diagnostics /

The FDA has approved Darzalex Faspro (daratumumab with hyaluronidase) combined with bortezomib, lenalidomide, and dexamethasone (VRd) for adults newly diagnosed with multiple myeloma who cannot have a stem cell transplant. The approval is based on a study of 395 patients showing that adding Darzalex Faspro to VRd improved outcomes: 52.3% of patients achieved MRD negativity versus

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Zirconium Nanoparticles Boost Photodynamic Therapy in the Fight Against Cancer

Technology Innovation /

Zirconium oxide nanoparticles are being used to improve photodynamic therapy (PDT) for cancer. PDT is a minimally invasive treatment that relies on a light-activated drug and oxygen to produce reactive oxygen species that kill cancer cells. While effective in theory, traditional PDT is limited by poor drug solubility, shallow light penetration, and low oxygen levels

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Electric Pulse Therapy Offers New Hope for Hard-to-Treat Pancreatic Cancer

Treatment /

High-voltage electrical pulses (HVEPs) are being used as a non-heat-based treatment for pancreatic cancer. HVEPs work by applying strong electric fields that create tiny pores in cancer cell membranes, a process called electroporation. Lower electric fields temporarily increase cell permeability and make tumors more sensitive to drugs, while stronger fields cause permanent damage that leads

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PROTAC Drugs Signal a New Era of Cancer Treatment by Destroying Disease-Driving Proteins

Targeted Therapy /

PROTAC technology represents a major shift in modern drug design, moving beyond protein inhibition toward directly eliminating disease-causing proteins. Unlike traditional drugs that must block a specific active site, PROTACs work by guiding unwanted proteins to the cell’s natural disposal system. Once the protein is tagged and destroyed, the PROTAC molecule is released and can

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Nanotechnology Reshapes Cancer Treatment by Targeting the Tumor’s Hidden Defenses

Technology Innovation /

advanced nanotechnology-based therapies, with a focus on how tumors protect themselves through the tumor microenvironment (TME). Conventional treatments like chemotherapy, radiation, and surgery often struggle because they lack precision, harm healthy cells, and have difficulty reaching advanced tumors. Despite decades of use, these methods have only modestly improved survival rates for late-stage cancers, highlighting the

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“Smart” Hydrogels Offer New Hope for Hard-to-Treat Pancreatic Cancer

Technology Innovation /

Pancreatic cancer is one of the deadliest cancers because it is usually found late and is difficult to treat. Most patients cannot have surgery, and even those who do often see the cancer return. The tumor is surrounded by a dense, fibrous barrier that blocks drugs from reaching cancer cells and creates an environment that

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Key Cancer Stem Cells Found to Drive Chemotherapy Resistance in Pancreatic Cancer

Research Advances /

Researchers have identified a small but powerful group of pancreatic cancer cells that are responsible for resistance to gemcitabine, the most commonly used chemotherapy for the disease. These cells, known as cancer stem cells, are marked by high levels of a protein called ARPC1B. Unlike other tumor cells, they can survive treatment and regenerate the

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Rethinking Fibroblasts: How Tumor Support Cells Shape Pancreatic Cancer Treatment

Research Advances /

Pancreatic cancer is hard to treat because it is surrounded by dense supportive tissue that blocks chemotherapy. The most abundant cells in this tissue are cancer-associated fibroblasts (CAFs), which strongly influence how tumors grow, spread, and resist treatment. Rather than being just passive barriers, CAFs actively shape the tumor environment. Researchers have found that CAFs

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