Molecular Oncology

International scientists discovered that bacteria living in tumors produce a molecule called 2-methylisocitrate (2-MiCit) that can fight cancer and enhance chemotherapy effectiveness. Through screening over 1,100 conditions using C. elegans worms, scientists found that E. coli bacteria produce 2-MiCit, which improves the effectiveness of the chemotherapy drug 5-fluorouracil (5-FU). The molecule works by inhibiting a […]

The human body, composed of approximately 37 trillion cells, lacks a clear understanding of how these cells coordinate within tissues. To address this, a comprehensive pan-tissue single-cell transcriptomic atlas of over 2.29 million cells from 35 healthy human tissues was assembled. Using a new computational framework, CoVarNet, researchers identified 12 recurring, cross-tissue Cellular Modules (CMs),

Recurrent low-grade, intermediate-risk non-muscle-invasive bladder cancer (LG-IR-NMIBC) has traditionally required repeated TURBT surgeries due to high recurrence rates, placing significant physical and emotional burdens on patients. Elderly patients, in particular, face frequent procedures under anesthesia and ongoing surveillance, which can severely impact quality of life. FDA-approved Zusduri (mitomycin intravesical solution) now provides the first non-surgical