Researchers have identified a potential new treatment approach for Epstein-Barr virus–positive (EBV+) gastric cancer, a subtype marked by extreme DNA hypermethylation that shuts down tumor-suppressor genes. In this cancer type, the virus triggers a process called CpG Island Methylator Phenotype (CIMP). This adds methyl groups to DNA, acting like an “off switch” that silences genes […]

Long-term results from the phase 2 M20-075 study show that the combination of ibrutinib (Imbruvica) and venetoclax (Venclexta) provides strong and lasting responses in patients with relapsed or refractory mantle cell lymphoma (MCL). After a median follow-up of 37.2 months, the overall response rate was 83.3%. Among patients who could be evaluated, 83% achieved a

A new study suggests that high-dose palliative radiation therapy can be an effective and tolerable option for patients with incurable mucosal head and neck squamous cell carcinoma (HNSCC) who are not candidates for standard chemoradiotherapy. In the study, 92.4% of patients completed the full radiation course of 50–55 Gy delivered over four weeks. At 12

A new clinic study found that giving chemotherapy before surgery can significantly improve survival for patients with early-stage pancreatic cancer, especially when the tumor is touching nearby blood vessels. In the past, many patients had surgery first. But researchers analyzed data from about 1,400 patients and found an important difference. When tumors were touching a nearby