A study has identified specific cancer-associated fibroblasts (CAFs) as key drivers of invasion and progression in aggressive Thyroid Cancer. By mapping the tumor stroma, researchers found that these cells create a microenvironment that promotes metastasis and resistance to treatment. The researcher used single-cell sequencing and spatial transcriptomics to analyze 81 patient samples, comparing slow-growing tumors with […]

Researchers have discovered a way that metastatic tumor cells avoid the immune system in Triple-Negative Breast Cancer (TNBC). The study, led by Judith Agudo and published in Nature, describes how cancer cells traveling through the body can hide from immune attack and form tumors in organs such as the lungs, liver, and brain. Using a

A new study found that a protein called Secreted Phosphoprotein 1 (SPP1) plays an important role in helping colorectal cancer spread to the liver and resist immunotherapy. Researchers discovered that SPP1 levels are much higher in liver metastases than in primary colorectal tumors. Patients with high levels of SPP1 in their blood tend to have