Researchers have found that a repurposed drug combination of disulfiram and copper may help overcome chemotherapy resistance in pancreatic cancer, one of the most lethal cancer types. The study focuses on pancreatic ductal adenocarcinoma, where resistance to the chemotherapy drug 5-fluorouracil (5-FU) often limits the effectiveness of standard treatment regimens like FOLFIRINOX. Scientists discovered that

Researchers are developing a new nanotechnology-based treatment strategy for pancreatic cancer that aims to overcome two major barriers: the tumor’s dense protective tissue and its ability to suppress the immune system. The approach uses smart nanomaterials designed to trigger a form of cancer cell death called ferroptosis, which depends on iron and causes toxic damage

Researchers have discovered that vitamin B2, also known as riboflavin, helps cancer cells survive by protecting them from ferroptosis, a type of cell death caused by iron-driven oxidative damage. The study, published in Nature Cell Biology, found that vitamin B2 supports a protein called FSP1, which strengthens the antioxidant defenses of tumor cells and prevents

A study published in Communications Biology has identified pyruvate carboxylase (PC) as a key driver of metabolic changes in epithelial ovarian cancer. Researchers found that high PC levels are linked to more advanced disease, metastasis, recurrence, and poorer survival. The study shows that PC helps cancer cells build up fats by boosting the production of triglycerides