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New Drug Combination Targets Genetic Weakness in Pancreatic Cancer

Precision Medicine /

Researches have presented a new treatment strategy for pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with a survival rate of about 13%. While most PDAC cases have KRAS mutations, around 22% also lose the MTAP gene. This MTAP deletion causes a buildup of a molecule called MTA, creating a unique weakness in cancer cells. Researchers developed a […]

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New Antibody Ginisortamab Shows Promise Against Advanced Gastrointestinal Cancers

Treatment /

Ginisortamab (UCB6114) is a new monoclonal antibody being developed to treat advanced solid tumors, especially gastrointestinal cancers. Instead of attacking cancer cells directly, it targets the tumor’s surrounding support cells to weaken the tumor’s defenses. The therapy focuses on a protein called gremlin-1, produced by cancer-associated fibroblasts around the tumor. Gremlin-1 blocks natural tumor-suppressing proteins

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New LED and Tin Nanoflake Therapy Offers Safe, Low-Cost Cancer Treatment

Technology Innovation /

Researchers have developed a low-cost, non-invasive cancer treatment that uses LED light and tin-based nanoflakes to destroy tumors without the harsh side effects of chemotherapy. The treatment works by giving patients ultra-thin tin oxide (SnOx) nanoflakes that target cancer cells. When exposed to simple LED light, the nanoflakes heat up and kill the cancer cells

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Scientists Grow Helper T Cells from Stem Cells, Paving the Way for Faster, Cheaper Cancer Therapies

Research Advances /

Researchers have found a way to consistently grow Helper T cells from stem cells in the lab, a breakthrough that could make advanced cancer therapies faster, cheaper, and more accessible. Helper T cells are important because they coordinate and strengthen the immune response, but until now they were very difficult to produce reliably. The team

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New Antibody Shows Promise Against Aggressive Triple-Negative Breast Cancer

Treatment /

Researchers have developed an experimental antibody that targets triple-negative breast cancer, one of the most aggressive and treatment-resistant forms of the disease. The antibody focuses on a protein called SFRP2, which helps tumors grow, survive chemotherapy, and evade the immune system. The treatment works by blocking SFRP2, which flips tumor-supporting immune cells called macrophages back into

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Scientists Uncover How Pancreatic Cancer Hides From the Immune System—and How to Expose It

Research Advances /

Research have discovered how pancreatic cancer hides from the immune system. The researchers found that this “invisibility cloak” can be disabled, causing aggressive tumors in animal studies to shrink by as much as 94%. The study focused on MYC, a protein known to drive rapid cancer growth. While MYC’s role in making tumors grow was already

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New Tool Predicts How Cancer Evolves by Tracking Chromosome Changes

Technology Innovation /

Researchers have created ALFA-K, a computer-based tool that predicts how cancer changes over time by tracking whole chromosomes. Instead of just observing tumors at one moment, this approach helps forecast how they will evolve. Cancer cells often gain or lose entire chromosomes, which can change thousands of genes at once. Until now, it was difficult

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New Immunotherapy Turns the Body’s Own Immune Cells Into Cancer Fighters

Immunotherapy /

Researchers have created a new type of immunotherapy that turns the body’s own immune cells into cancer-fighting cells directly inside the tumor, without needing lab-based cell engineering. Solid tumors such as lung or liver cancer are hard to treat because they form dense tissue that blocks immune cells. They also weaken nearby macrophages, stopping them

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Pre-Surgery Chemotherapy Boosts Survival in Resectable Pancreatic Cancer

Treatment /

The Prep-02/JSAP05 trial, a phase II/III study, evaluated preoperative chemotherapy versus surgery-first in patients with resectable pancreatic ductal adenocarcinoma. A total of 364 patients were enrolled: one group received two cycles of gemcitabine plus S-1 before surgery, while the other underwent immediate surgery. Both groups were advised to complete six months of postoperative S-1. Results

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“Super Vaccine” Shows Near-Complete Protection Against Cancer in Mice

preclinical trails /

Researchers have created a nanoparticle “super vaccine” that prevented tumor formation in up to 88% of mice. Unlike traditional vaccines that use a single signal to alert the immune system, this new approach mimics a real infection, triggering a strong, body-wide immune response. The key is the lipid nanoparticle delivery system, which carries two immune-activating

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