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A phase 2 clinical trial found that adding the PD-1 inhibitor sintilimab to adjuvant capecitabine did not improve outcomes for patients with locoregionally advanced nasopharyngeal carcinoma who responded poorly to induction chemotherapy. The study enrolled 152 high-risk patients and randomly assigned them to receive either sintilimab plus capecitabine or capecitabine alone after chemoradiotherapy. The trial […]

A Phase II clinical trial has found that sacituzumab govitecan, an FDA-approved breast cancer drug, may offer a promising new treatment option for advanced uterine cancer. The study enrolled 50 patients whose disease had progressed despite standard therapies. Researchers reported that 70% of participants experienced tumor shrinkage, while 28% achieved a significant reduction of at

A Phase II clinical trial conducted by researchers at the Yale School of Medicine has identified a promising new treatment for advanced uterine cancer using sacituzumab govitecan, a drug already approved for breast cancer. The study included 50 patients whose cancer had progressed after standard therapies. Results showed that 70% of participants experienced tumor shrinkage,

Interim results from the Phase 2/3 Duravelo-2 trial show that zelenectide pevedotin (BT8009) combined with pembrolizumab demonstrates strong anti-tumor activity and improved tolerability in patients with locally advanced or metastatic urothelial carcinoma. Zelenectide pevedotin is a “Bicycle drug conjugate” designed to penetrate tumors rapidly and clear quickly from healthy tissue, reducing the severe side effects commonly

Findings from the StrateGIST 1 trial show that velzatinib (IDRX-42), a broad-spectrum oral therapy, demonstrates strong clinical activity across multiple lines of treatment in patients with advanced gastrointestinal stromal tumors (GIST). The drug is designed to overcome resistance driven by KIT gene mutations, which account for about 75% to 80% of GIST cases. While current therapies

Findings from the Phase 3 SARC041 trial show that abemaciclib (Verzenio) significantly delays disease progression in patients with advanced dedifferentiated liposarcoma (DD-LPS), a rare and aggressive soft-tissue cancer. The drug targets CDK4, a protein amplified in nearly all DD-LPS cases that drives tumor growth. By inhibiting this pathway, abemaciclib slows cancer progression more effectively than

Results from a Phase 2a trial suggest that adding atebimetinib to modified gemcitabine and nab-paclitaxel (mGnP) chemotherapy may improve outcomes for patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC). Atebimetinib is a novel MEK inhibitor designed with a short half-life, allowing it to temporarily block cancer-growth signaling while reducing the toxicities and resistance often seen

Results from the Phase 3 OptimUM-02 trial show that the combination of darovasertib and crizotinib significantly improves outcomes for patients with HLA-A*02:01–negative metastatic uveal melanoma, a rare and aggressive form of eye cancer with no approved treatment options for this population. The targeted therapy works by blocking the PKC signaling pathway, which is activated in more