Researchers have developed a new way to eliminate harmful “zombie cells” linked to cancer and aging. These senescent cells stop dividing but remain active, releasing substances that can damage tissue and help tumors spread.
Scientists discovered that the cells survive by overproducing GPX4, a protein that protects them from Ferroptosis, a form of cell death triggered by iron and oxidative stress. After screening 10,000 compounds, researchers identified drugs that block GPX4, causing the zombie cells to self-destruct while sparing healthy cells.
In mouse studies, combining the treatment with chemotherapy reduced tumor size and improved survival. Researchers believe the strategy may also help treat age-related diseases such as fibrosis.