Researchers have developed a new nanomaterial that destroys cancer cells by triggering a dual chemical attack inside tumors. The study, published in Advanced Functional Materials, improves chemodynamic therapy (CDT).
Unlike traditional CDT agents that produce only one harmful molecule, this iron-based material generates both hydroxyl radicals and singlet oxygen. These highly reactive molecules damage DNA and increase oxidative stress, leading to cancer cell death. The material activates only in the acidic, hydrogen-peroxide-rich tumor environment, sparing healthy tissue.
In mouse models of human breast cancer, the treatment completely eliminated tumors without noticeable side effects. The research team plans to test the approach in more aggressive cancers, such as pancreatic cancer, before moving to human trials.